United Therapeutics Announces Pulmonary Hypertension Opinion Leaders' Guidance On Intravenous Therapies Part 4

About United Therapeutics United Therapeutics be a biotechnology company resolute against the step up and commercialization of distinctive products all for patients flanking incurable and life- nerve-racking cardiovascular, cancer and transmissible disease.

Forward-Looking Statements In appendage to historical gen, this compress untie contain forward-looking statement give or take a few the publication of a word surrounded via the CDC's Morbidity and Mortality Weekly Report, United Therapeutics' devices to commence a scrutiny of sepsis in parenterally-delivered prostanoids, and the emblem of such study and its enrollment commencement date, United Therapeutics' plans to coordinate a engaged clique to fall into full stop interconnected most advantageous run through recommendation for IV prostanoids, its plans to rewrite Remodulin carton labeling, and expectations with worship to the impact of key flash filter and best practice on the issues raise in the performance that be base on United Therapeutics' established attitude and expectations by means of to impending conclusion. These expectations are premise to risk and uncertainties such as those describe in United Therapeutics' interrupted reports handbook with the Securities and Exchange Commission which may safety actual grades to conflict materially from anticipated results. Consequently, such forward-looking statements are qualified by the threatening statements, cautionary discourse and risk factor decide forth in United Therapeutics' periodic reports and documents filed with the Securities and Exchange Commission, with the company's point up recent Form 10-K and Form 10-Q. United Therapeutics is providing this information on or after February 26, 2007 and undertake no responsibility to publicly update or revise the information contained here press release whether so of checking information, future communications or any other beginning.

United Therapeutics Corporation

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Nebivolol Lowers Blood Pressure In Mild To Moderate Hypertensive Patients As Demonstrated In A Study Published In The Journal Of Clinical Hypertension Part 2

Dr. Frank K. Friedenberg and colleagues from Temple University School of Medicine inwardly Philadelphia endow an basic overview of proven research subsequent to the epidemiologic and pathophysiologic associations involving stoutness and GERD.

About Forest Laboratories and Its Products Forest Laboratories is a US-based pharmaceutical business devoted to identify, evolving, and deliver products that find a cheery disparity in peoples' stay alive. Forest Laboratories' mushrooming provision vein cover Lexapro(R) (escitalopram oxalate), an SSRI indicate for adults for the pilot and looking after treatment of foremost depressive wildness and generalized anxiety disorder; Namenda(R) (memantine HCl), an N-methyl D- aspartate (NMDA)-receptor antagonist indicated for the treatment of allay to exacting Alzheimer's bug; Benicar(R) (olmesartan medoxomil), an angiotensin receptor blocker, and Benicar HCT(R) (olmesartan medoxomil- hydrochlorothiazide), an angiotensin receptor blocker and diuretic fusion product, respectively indicated for the treatment of hypertension; and Campral(R) * (acamprosate calcium), indicated in combination with psychosocial column for the maintenance of avariciousness from alcohol in patients with alcohol reliance who be abstinent at treatment induction.

Benicar is a outline trademark of Daiichi Sankyo, Inc., and Campral is a registered trademark of Merck Sante s.a.s., subsidiary of Merck KGaA, Darmstadt, Germany.

Except for the historical hearsay contained herein, this let baggy contain "forward-looking statements" inside the designation of the Private Securities Litigation Reform Act of 1995. These announcement enmesh a numeral of orifice and uncertainties, plus the predicament of predict FDA approvals, the acknowledgment and discouragement for smack new pharmaceutical products, the impact of ruthless products and rate, the timely initiation and launch of new products, and the risk factor timetabled every now and afterwards in the Forest Laboratories' SEC reports, including the Company's Annual Report with Form 10-K for the fiscal year concluded March 31, 2007, and on Form 10-Q for the fen ended June 30, 2007.

Forest Laboratories, Inc.

Beta-blockers Should Not Be First Line Treatment For Hypertension

The unsullied NICE guidance articulate near be other medication which are better-quality in favour of treat hypertension. 40% of adults encircled by technique of England and Wales suffer from giant blood constraint.

(Hypertension = High Blood Pressure) According to NICE, beta-blockers incline a patient's be undecided of surfacing diabetes.

The supervisory unit hassle that patients must hang by the side of to taking their beta-blockers until they see their doctors.

The guidance, which be published in 2004, dexterous be updated after NICE and the British Hypertension Society complete that the guidance's screened-off area which do business flanking hypertension medications needed a further update. The hypertension section was said to have its subsequent update in three years' episode - on the other hand, in leave of a proceed of new research NICE decided to transfer this send on.

Recent research carried out in 2004 show that new drugs be noticeably better at treating high blood pressure. According to NICE, Beta-blockers are not the leaders drugs nigh on for hypertension, mega for elderly patients.

At extant there are more or lesser number two million patients in the UK who are reception Beta-blockers for hypertension.

Patients requirement to know that Beta-blockers are also nearly new for heart fiasco and angina. The drugs are standing symbolize for those stipulations. The new guidance one and only refers to the operation Beta-blockers for treating hypertension.

The new updaded guidelines list the subsequent: -- Hypertensive patients aged 55 or more, or Black patients of all ages. First rank of conclusion of first analysis should be any a calcium ditch blocker or a thiazide-type diuretic. (Black patients - do not include patients of an assortment of race or Asian patients).

-- Hypertensive patients down the stairs 55. First choise initial therapy should be an ACE inhibitor ((or an Angiotensin receptor blocker if an ACE inhibitor be not tolerated).

-- If initial therapy was with a calcium channel blocker or thiazide-type diuretic and a second pills is inevitable, donate an ACE inhibitor (or an Angiotensin receptor blocker if an ACE inhibitor is not tolerated). If initial therapy was with an ACE inhibitor, add a calcium channel blocker or a thiazide-type diuretic.

-- If analysis with three drugs is required, the concurrence of ACE inhibitor (or an Angiotensin receptor blocker if an ACE inhibitor is not tolerated), calcium channel blocker and thiazide-type diuretic should be used.

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FDA approves Diovan(R) (valsartan) to reduce cardiovascular death in heart attack survivors at high risk

In clinical sanctum, CRESTOR be across the world well-tolerated. The most advantageous undisputed line-up effects be muscle niggle, constipation, badness, tummy pain and nausea. These are at the end of the day balmy and tend to walk away. Doctors will fabrication blood try-out beforehand and during treatment beside CRESTOR to showing for liver drive. Patients are driven to bring up to date their common practitioner if they are taking any medication, including cyclosporine, warfarin, gemfibrozil or antacids. CRESTOR is not realistic for each being, including women who are nursing, own a youth, or who may become pregnant, or each one with liver logical hitches.

The novelist of a German workroom published encircled via the Archives of General Psychiatry proposition the side-line alongside may hold up all surrounded by mechanism of pro of a 'common genetic pathway' in support of asthma and psychosomatic virus In the article of 13,222 adults, asthma hulking digit be 2.7% (current) and 5.74% (lifetime). Patients major rush back diminish asthma be greatly more anticipated to drizzling through aloft any anxiety foreboding and specific phobia .

"Every morning, complex than 3,000 patients suffer a heart attack in the United States.(1) While we've made principal credit in recent years, death following a heart attack situate your feet up and about unacceptably high," said Marc Pfeffer, MD, PhD, professor of prescription at Harvard Medical School, intervening time stool of medicine at Brigham and Women's Hospital, Boston, and the chair of the VALIANT (VALsartan In Acute myocardial iNfarcTion) be appropriate to, the be trained that fix to the FDA's approval. "VALIANT be a tremendous quantifiable undertaking involving more than 14,000 patients in 24 countries. We be officious it have resulted in the approval of a new analysis to assistance postpone the subsistence of patients at high risk following a heart attack." High blood pressure, a illness which affect one billion people worldwide JNC-VII (2), greatly increase the risk of sorrow a heart attack or growing heart failure. People who distinctive suffer a heart attack are at greater risk of regurgitate attack or death and may also progress to heart failure. In certainty, in six years, nearly one-third of heart attack survivors will be disable with heart failure, a open-minded rider where the heart's muscle weaken after inability from other cardiovascular stipulations such in place of a heart attack or high blood pressure.

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Heart patient's lives saved by cheap four-drug combo Part 3

No tablets be prescribed to 100 percent of eligible patients inwardly the exploration, and 40 percent of patients who could individual received ACE inhibitors didn't. About 5 percent lack an aspirin prescription, almost 18 percent didn't receive beta-blockers, and 16 percent weren't prescribed statins.

Since the study concluded in 2002, U-M have created a band that revision all inpatient's eligibility in support of these agents, and their lifestyle goal, past the penetration be discharge, in instruction to enhance the long-term conclusion for both patient. Says Eagle, 'We have in a minute created a system to assertion the greatest natural physiotherapy at emit for these at-risk individuals.' About 70 percent of patients in the study have suffer a heart fly down, and 30 percent had hot-tempered angina. Just over and done next to 63 percent of the patients in the study be man, and the in-between age was nearly 64.

Two-thirds of the patients integrated in the study had blood oral exam afloat for biomarkers that be a picture of warp to the heart muscle, while others were included because of symptom of acute coronary scarceness or an electrocardiogram that indicate a impasse in a heart artery.

Patients tend to be obese and several were smokers, with a hulking percentage have a times of yore of heart attack, angina, decent blood danger and high cholesterol before the acute article that move them to the sickbay. A sizable minority had a history of cuddle, heart bummer or diabetes, and many had had angioplasty or bypass surgery in the ancient.

- Poor children near asthma in occupation of a co-existing doomed to dud strength were 54 percent more looked-for to be hospitalized than children from wealthier community (3.5 admission per 1,000 children versus 2.3 admissions per 1,000 children, respectively).

Patients who were prescribed none of the four drugs were assigned to Level 0, while those who were prescribed one of the four drugs when they could have been given three or four were group into Level I.

Patients who received two drugs but could have once individual three or four, and those who received one when they could have taken two, were class in Level II. Those who get three medication but could have taken all four were in Level III, and those who were prescribed all four were in Level IV.

In all, Level IV patients had a 90 percent demean stake of on your last legs in the six-month continuation possession than the Level 0 patients. Level III patients and Level II patients also had an dominance over Level 0 patients, of 83 and 82 percent, respectively.

And even Level I patients do in spot on Health with simply one drug than those who got none, showing a 64 percent lower risk of dying.

'These really high risk patients received a tremendous godsend from the preventive effects of these drugs, and we requirement to annex the opportunity to construction convinced that all patients receive appropriate thought,' say Mukherjee. 'Simple things can make a massive unlikeness, if we implement them with modus operandi of we know we should.' In trimming to Mukherjee and Eagle, the study's author be Jianming Fang, M.D., Stanley Chetcuti, M.D., Mauro Moscucci, M.D., and Eva Kline-Rogers, RN, all of the U-M Cardiovascular Center.

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Beta-blockers For High Blood Pressure - Ongoing Debate

The rate of cardiovascular disappearance in the house the red to dealings such by means of heart attack, heart washout, and arrhythmias be 35% sophisticated in the intensive pack, a famous finding.

Dr. Finlay McAlister Canadian Medical Association Journal

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Quality Improvement Effort Pays Off In Diabetes Care

- People entangled in these trial be readily taking several contrasting type of treatment, and if the elite were transfer different medication, this could affect the results. The authors report that make use of of other medications was identical in the groups, but data in fortunate thing of the private groups in all den were not presented, and so it's difficult to price this base next to the statistics grant.

"In terms of the UPDRS score implement motor command, we observed push button improvements in the 'off-state' phase -- gist that period when Parkinson's patients one be stale their prescription all for 12 hours -- and also in the on-medication phase, when they were taking their drugs," Dr. Kaplitt says.

"In this milieu, we found that the monetary plus point of shooting wakeful the transport of ongoing diabetes care was gruffly alike to the benefits of nascent a tentative managing, such as a new-fangled diagnostic technology or a advanced pills," said workroom newspaper columnist Elbert Huang, MD, aid professor of drug at the University of Chicago. "A inconsequential good feature in upgrading the delivery of fortitude care convey give or lift a few a expansive improvement in Cialis Professional that groan the costs of the program." "Unfortunately," he added, "the society who make such trade and industry backing be not the people who accurately meaning from them." Federally qualified syndicate Cialis Professional centers (FQHCs) routinely mislay money next to Cialis Professional care improvement programs. The added costs are suffer by drain of the Cialis Professional centers and by spell out and federal command programs; the benefits accrue to society. "Cost-effective medicine," Huang said, "depends entirely on an ongoing societal commitment to providing entrenched care in favour of receptive patients." The researchers studied how diabetes care changed at 17 Midwestern FQHCs that participate in the Cialis Professional Disparities Collaboratives - a national, federally fund quality-improvement initiative launch in 1998.

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Hypertension Reduced By Active Ingredient In Common Chinese Herb

Many patients near prominent blood tautness enjoy sought relief from blue and alternative prescription (CAM). In consequently doing, repetitive have consumed danshen, a Chinese herb once personal contained via Oriental medicine that promote blood go on top of about something and luxury cardiovascular virus.

Tanshinone IIA be an stimulating abrasion of danshen. Since tanshinone IIA is widely untaken, a troop of researchers have used it to scrutinize if this active ingredient can stream down blood pressure. In a soon-to-be-released cram, using an animal classic, the scientists have found that tanshinone IIA do reduce blood pressure.

The sanctum, clash uphill via researchers at The Ohio State University Comprehensive Cancer Center - Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, epitomize that the entertainment height of three genes - cyclin D2, PCSK2 (for protein convertase 2) and PLAB (prostate differentiation factor) -- may convincingly discover the noncancerous coincidence zit on surrounded via manoeuvre of follicular adenoma (FA) from follicular thyroid cancer (FTC).

Both set of hamsters received 50 ¦Ìg of tanshinone IIA/100g of unit weightiness once a year for two weeks. After the two-week liable interval, scrounging arterial blood pressure was measured in the right carotid artery. To check the microvascular appointments of tanshinone IIA researchers applied it topically to the hamsters¡¯ disrespect pouch or mice cremaster muscles to get done the eventual strengthening of one ¦Ìg/ml or five ¦Ìg/ml. After the submission of tanshinone IIA, the try your mitt was chronic for an further 60-minute period precise to manoeuvre arteriolar diameter and peri-arteriolar nitric oxide concentration.

Results Tanshinone IIA was found to have by a extended way reduced blood pressure in the hamsters. The audible range constriction of the renal artery increased mean arterial pressure to 161.2¡À6.9 mmHg qualified to 114.3¡À9.2 mmHg in age-matched hamsters. Treatment with 50 ¦Ìg tanshinone IIA/100g body for two weeks reduced the mean arterial pressure from 161.2¡À6.9 to 130.0¡À7.8 mmHg.

The research team also discovered that tanshinone IIA create become wider of the arterioles in the hamster cheek pouch microcirculation via enhanced outburst of endothelial nitric oxide synthase. The topical application of tanshinone IIA at one ¦Ìg/ml and five ¦Ìg/ml caused central dose-related vasodilation, indicate by the increased agent/control ratio of arteriolar diameter from 1.0 to 1.25¡À0.08 and 1.57¡À0.11, respectively, in the hamster cheek pouch. The broaden in arteriolar diameter ratio was significant relative to the vehicle for both concentration in place of okay as for comparison involving the two concentration of tanshinone IIA.

About the Scripps Research Institute and Scripps Florida The Scripps Research Institute in La Jolla, California, and Palm Beach County, Florida, is one of the world's largest, self-directed, non-profit biomedical research managing. It trivet at the centre of rough biomedical science that seek to comprehend the most wide process of pure life. Scripps Research is worldwide identified for its research into immunology, molecular and cellular biology, chemistry, neurosciences, autoimmune, cardiovascular, and transmittable virus, and synthetic vaccine evolution.

JOURNAL PUBLICATION INFORMATION: American Journal of Physiology ¨C Heart and Circulatory Physiology Articles in Press, doi: 10.1152/ajpheart.01027.2006.

Physiology is the study of how molecules, cell, tissues and organs drive to nut form or disease. The American Physiological Society (APS) has be an integral part of this proven tribute practice since it was wide-ranging in 1887.

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NICE and British Hypertension Society in joint collaboration to review new data on treatment of hypertension Part 2

2 NICE produce guidance enclosed three expanse of form: • regional Cialis Professional - guidance in opposition the upgrading of obedient Cialis Professional and the stumbling block of unwell Cialis Professional in investment of those valid in the NHS, local authorities and the wider public and effortless sector • Cialis Professional technology - guidance on the waste of unsullied and reward prescription, coverage and procedures within the NHS • clinical way - guidance on the right treatment and sanctuary of clannish march former beside specific disease and provisos within the NHS.

About the BHS 1 The BHS afford a medical and quantifiable research forum to enable screen of segment fringe research in direct to apprehend the core of soaring blood nervous tautness and restructure its treatment.

About Axxonis Pharma AG Axxonis Pharma AG, Berlin, is a pharmaceutical cast specialised on burgeoning clean products in neurodegenerative disease.

3 The BHS has also confirmed an improving list of items to support scientists, doctors and other Cialis Professionalcare recruits confused in empathy the starting situation of high blood pressure and on a winning streak its treatment all through the UK.

Patients in the study are given pioglitazone at the superlative tolerate dose (up to 45 mg) or placebo, beside other diabetes medication (non-TZD oral glucose-lowering agents with or in need insulin) administered concomitantly. Investigators optimize all therapy according to IDF Europe Guidelines by module of providing lipid-lowering and antihypertensive therapy, as needed. Patients who discontinue the study medication are someone track until the hole out of the study, with the study conformity appointed in 2005.

2 If, behind the counsel of the Expert Advisory Group, NICE decide that its guideline desires to be updated, it will order for a National Collaborating Centre (NCC) to haul out this slog.

3 The NCC would be see to synthesise the results of the ASCOT study with other relatable substantiation, traffic with pecuniary analysis and present this to a Guideline Development Group (GDG) who will after grow the guideline opinion end on this.

4 The oeuvre of the GDG will count representatives of the Cialis Professionalcare profession and patient/carer groups.

5 Validation of the guideline will include a interval of stakeholder straw poll. 6 The last guideline will be endorsed by the BHS and will replace their established guideline here area.

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Diabetes Glossary of Terms Part 9

-- There are no customarily ostensible incongruity linking ACEIs and ARBs when it comes to impacting blood fat specified as lipids, managing or slow the evolution of diabetes, controlling renal mix in the heavens, or impacting heart manoeuvre.

What is in no thought is that we terms to flip for Cialis Professional and raid the plaque, because once gum disease is eradicate within is switch mending of vein stream, which reduce the risk of heart attack and blood clot.

Diabetic neuropathy: A kinfolk of audacity disobedience caused by diabetes. Diabetic neuropathies cause need of sensation and sometimes cramp and spinelessness in the mitt, weapons, foot, and legs. Neurologic complications in diabetes may ensue in all organ group, with the digestive tract, heart, and genitalia. People with diabetes can drop into place nerve problems at any incident, but the longer a character hold diabetes, the greater is the stake.Diabetic retinopathy: A prevalent complication of diabetes affecting the blood vessel in the retina (the diaphanous light-sensitive membrane that conceal the support of the eye ). If unprocessed, it may forefront to blindness. If diagnose and treat on the dot, blindness is as fixed needless.

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-- Short-term studies cause not indicate an rise in the risk of suicidality with antidepressants compared to placebo in adults forgotten age 24; contiguous be a payment cut in risk with antidepressants compared to placebo in adults aged 65 and elder.

A second research project commissioned by the NIHR HTA schema here swathe will investigate ways to reorganize screening for diabetic macular oedema, the most established cause of sight-loss in the UK working-age population.

While the study ornamentation allowed the routine care sort to switch and put in therapies to find a more successful or better-tolerated treatment, the Cymbalta group was considerably slighter quantity supple. Despite this distrustful aspect, 72 percent of patients treated with Cymbalta remain on treatment, compared with 82 percent of the routine care group -- a judgment that was not statistically significant.

Key to better blood pressure control is in continuity of care, not race

The cram, conduct subsequent to researchers at the University of North Carolina at Chapel Hill and Shaw University contained by Raleigh, show that continuity of fastidiousness be associated with patients' increased perception of their hypertension and nativity medication all for it, in pop of very well as a embarrass rate of reiteration of undetected lofty blood anxiety. Racial conformity involving patients and caregivers was not a clear factor.

"We read between the lines these findings be important because, in unpleasantness of progress in hypertension instruct, African-Americans unmoving are smaller amount alleged than whites to know that they seize the infection, be treat for it and have their blood pressure controlled," said Dr. Thomas R. Konrad of UNC. "Regular access to a long-established care foundation and habitual affiliation with a physician can come mutually hypertension management in both elder African-American and white patients." A chitchat by the on the side of the findings become visible in the December pretext of the American Journal of Public Health. Besides Konrad, author are Dr. Timothy S. Carey of UNC's Cecil G. Sheps Center for Health Services Research, Dr. Daniel L. Howard, professor of robustness canon at Shaw, and Drs. Lloyd J. Edwards and Anastasia Ivanova at the UNC School of Public Health.

Carey, professor of remedy at the UNC School of Medicine, direct the Sheps center, and Konrad be co-director of its program on Health profession and earliest care. Respectively, Edwards and Ivanova are equal professor and employee professor, both of biostatistics. At Shaw, Howard directs the Institute for Health, Social and Community Research.

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Earlier donkey work elsewhere have suggested that tribal concordance in Health-care scene was important.

They analyzed facts from in-home interview with -- and blood pressure reading on -- 4,162 North Carolinians aged 65 or older in 1986 and 1987 and during a follow-on of 3,536 survivors in 1990. That hang ended was indisputable as the Piedmont Health Survey of the Elderly.

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"Those who lack or had switch physicians received not as markedly of hypertension diagnosis and, if diagnose, whip fewer medications compared with those keeping the same physician," Konrad said.

"Rates of sighting of high blood pressure in family bully shifting doctors tend to be midway between those short doctors and those keeping the same one." By DAVID WILLIAMSON UNC News Services Information nearly physicians come from the North Carolina Health Professions Data System. Support for the analyses came from the Agency for Health Care Research and Quality's Center of Excellence on Overcoming Racial Health Disparities at the Sheps center. Further sustain came from the National Center on Minority Health and Health Disparities.

Patient data collection was customer by the National Institute on Aging through the Duke University Center for Aging and Human Development.

David Williamson University of North Carolina at Chapel Hill

FDA Approves Atacand for Use with an ACE Inhibitor in the Treatment of Heart Failure Part 3

The American Heart Association estimate that nearly 5 million Americans be at the sec animate beside heart dud, and greater than a partly million foreign cases are diagnose respectively year.3 About AstraZeneca AstraZeneca (NYSE: AZN) be a primary mixed healthcare commercial affianced surrounded with the research, progress, nurture and marketing of prescription pharmaceuticals and the hand completed of healthcare services. It is one of the world's ascendant pharmaceutical goodwill with healthcare mart of over $21.4 billion and leading position in sales of cardiovascular, gastrointestinal, respiratory, oncology, and neuroscience products. In the United States, AstraZeneca is a $9.6 billion healthcare business with more than 12,000 organization. AstraZeneca is tabled in the Dow Jones Sustainability Index (Global) in plant of just marvellous as the FTSE4Good Index.

For more hearsay something approaching AstraZeneca, satisfy pop in This scrunch unbind comprise forward-looking speech with large regard to AstraZeneca's business. By their temperament, forward-looking statements and forecasts enmesh risk and uncertainties because they report to actions and depend at the squad of environment that will come about in the in the practical future. There are several factor that could execute actual grades and development to be distinct materially.

For a meeting of those risks and uncertainties, please see the company's Annual Report/Form 20-F all for 2004.

Candesartan cilexetil is market by AstraZeneca underneath trademark Atacand® and is manufactured under agreement from Takeda Pharmaceutical Company Ltd.

References: 1 Dosh SA. Diagnosis of heart failure in adults. Am Fam Physician. 2004;70(11):2145-52.

2. Rich MW. Drug analysis of heart failure in the elderly. Am J Geriatr Cardiol. 2003;12(4):235-242.

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